Aetiology of Mullerian Dysgenesis – A Theory

The measurements, given by the sonologist, in every case of correction of mullerian dysgenesis (during the monthly scannings over the last 5 years), were graphically recorded. It showed, in all cases, a rise and fall, in every measurement, during correction. A sample graph is given below.

The graph shows the final measurement (be it length, breadth or thickness),in comparison with the starting point, an appreciable improvement, thereby proving that the medicines given, have been beneficial to the patient, as the size of the nodules have grown. This change, by itself, is welcome, since till date, there has been no record of growth of uterine nodule. But, surprisingly, on further scrutiny, we find, that the increase, is neither uniform nor does it show a plateau formation (which is commonly seen), in between spells of growth. In other words, it is not a ladder like growth with occasional landings. On the contrary, it shows regression at many points, occasionally marked. This is surprising and needs a scientific explanation.

Analysis :

Starting Point.

The size of the nodule at the commencement of correction is crucial for the study. The nodule, at that moment, could have been

(1) growing spontaneously,

(2) regressing, or

(3) reached the end point of spontaneous progress  or regression (quiescent or standstill stage), -all of which are possible.

In nature, spontaneous evolution is seen; but then, it offers no explanation for the changes mentioned above (the regression). Similarly, if we consider point (3), having reached the end point, it is unlikely to have any impact on growth, as seen (moreover, having reached the nadir, unlikely to manifest again). So, the only conclusion, that we can make, is, that it was in a regressing phase and hence, retained its regressive element or factor at the commencement of correction and showed it during correction.

Regression Factor.

In nature, we do have a regression factor. In developmental defects of the mullerian tract, the combined incidence of mullerian agenesis, mullerian dysgenesis and regression after eugenesis is given as < 1 %. Regression after eugenesis produces various categories depending on when the regression factor commences to act. So, there is a factor, it has not been isolated or identified, till date. It can continue to act, after birth also. Nature reveals anomalies -  (both fusion & non-fusion defects), segmental loss in the mullerian tract, presence of irregular segments, functional regression (only about 20 % of female babies show withdrawal bleeding), few cases of secondary amenorrhoea with no obvious infection, premature menopause and menopause and finally, atrophy after menopause. Presence of regression factor is evident from the mensurational regression seen, at times, only in one dimension (unexplainable), during the serial scans. 

Growth of Uterine Nodule.

Irrespective of the stage of the starting point, there has been growth of nodule. Normally, in nature, genetic drive is presumed to be the factor for spontaneous evolution on specific lines. Hence, one possibility is that the genetic drive, which has been lying dormant all these years, has been stimulated, by the medicines, resulting in the growth of the nodules.

The Effect of Corrective Medicine.

Dr. Sreevalsan’s Regime has resulted in growth of uterine nodule, in all aspects – size, shape, position (movement towards the midline and anteversion), and development of cavity and lining and finally, response to ovarian hormones (menarche). It, probably, has no action on regression factor, as regression is still seen and it, may be safely presumed, that, it is only, stimulating the genetic drive.

           The Interplay.

During correction, the interplay between genetic stimulation and regressive factor and their relative stengths (at any given moment) could be the deciding factor behind the manifestation seen in the graphs. This is the only explanation that fits the case under discussion. It may be a presumption, but, is definitely, a viable theory. Only time and further study, will prove its true nature.

THERE IS NO GREATER SIGN OF IGNORANCE THAN BELIEVING THAT THE INEXPLICABLE IS IMPOSSIBLE. “   S.BILLARD.

Response in Lay Press

(1). Mathrubhoomi. (Malayalam). Daily Newspaper-Chennai Ed.-

(2). Muttram. (Tamil). – Official Organ of The Tamil Nadu Corporation for Development of Women.

The Basis of Treatment

Ashtanga Hridayam. Ch.  -12. - couplet – 63.

‘Vikara naama kusalo na jihriyaal kadachana

Na hi sarva vikaaraanaam naamathosthi dhruvaasthithi hi’.

According to Ayurveda, there is no need to name every disease nor is it possible, because new diseases are appearing and known diseases are getting eradicated.

Ashtanga Hridayam. Ch. -12. -  couplet –  66  &  67.

‘Dooshyam desham balam kaalamanalam prakirthim vayah

Satwam saathmyam tadhaahaaramavasdhaascha pradhagwidhaah

Sookshmasookshmasameekshyaishaam doshoushadhaniroopaney

Yo varthathey chikithsyaayaam na sah skhalathi jaathujil’.

Any physician can treat a sick person if he is able to assess the following ten aspects,

01. Dooshyam. (dhathu and mala, which are vitiated)

02. Desam. (site and place of affection)

03. Balam. (strength of the disease and of the body)

04. Kaalam. (stage of the disease and season)

05. Analam. (digestive fire)

06. Prakirthi (individual’s constitution)

07. Vayah. (age of the individual and duration of disease)

08. Satwam. (stamina)

09. Saathmyam. (suitable)

10. Aahaaram. (diet).

Treatment of any such case, cannot be construed as research and conditions laid down for the same. As long as genuine medicines are used in good faith and recorded with dosages and timings and once success is achieved and patent is obtained as a token of appreciation, one should be permitted to publish the findings so that, others can try out the same and verify the regime.

In our country, Allopathic journals do not publish reports wherein alternate systems are used although the diagnosis and investigations are Allopathic.

I submitted the same to the Intellectual Property Office and obtained a Patent entitled “An unique combination of Ayurvedic Compounds for Correcting of a rare form of Mullerian Dysgenesis.” from the Government of India.

As this case happens to be one, for which Allopathy has no remedy, what is actually happening (due to the non-publication) is that the sufferer from this condition, is neither made aware of the availability of this unique medical option nor is able to avail the same (due to non-awareness) and get relieved by correction. The question is whether this state of affairs will get corrected, probably, only if, one of the close kith and kin of the people at the helm of affairs (who had read this article and did not take any worthwhile action), suffers from this problem. The medical intelligentia should rise from their bias towards alternate systems, to help the suffering humanity.

[In China, it has been reported that this problem has been solved by integrating allopathy and chinese medicine and every doctor must learn and know the two systems. (A doctor’s mindscapes).

In India, at Madras (now Chennai), there was a College of Integrated Medicine offering ‘G.C.I.M.’ Course (the writer is an alumnus of that institution) which equipped the individual with sufficient knowledge to practise both systems of medicine. Unfortunately, the men at the helm of affairs did not intelligently tackle the situation and raise the status of the course (to make it an ideal course) and took the easy way out by closing the College and the Course and reverting to a state, of each indigenous system, to develop on its own and herein can be seen another anomaly creation – no college for Ayurveda was created, while for Siddha and Unani, colleges were started (Siddha at Palayamkottai and Unani at Chennai). If only, they had done so, at that time, what is suggested now, we would have, probably, found many more remedies

The Divine Truth

The Truth is that human beings possess divine powers. Divine powers may be acquired by any human being. When he sets his mind to it and concentrates with all his mental energy directed towards achieving his aim, he will feel, depending on his sincerity and need, a change and correct ideas become available to him, at that time. There is initially, a confusion, as to how it happened, but in due course, realising that an answer has come (for one’s query), one adopts it without further scrutiny. Repeated analysis and of course, failure to understand the source of guidance, one resigns to fate or nature and employ the method for further guidance and beneficial results. Notably, there is absence of stress and in fact, real mental peace. One more feature needs specific mention viz., lack of energising of one’s ego. Rishis and Godmen have demonstrated this supernatural effect.

Many (who are familiar with Ayurveda and its texts) have asked me, my technique of formulating ‘Dr. E.C.Sreevalsan’s Regime’ for correction of Mullerian Dysgenesis, which, till date, has shown only improvement in all cases, (without a single setback), during the correction. I must admit, I am not in a position to explain more than what is given above. Since there is lack of ego or pride, one can do one’s duty, without any strain or initiation of jealousy or rivalry. All, who find this solution, will be ready to cooperate, to help fruition of the attempt to bring this small group of defective individuals, back into the mainstream. Although, that is the main aim, one must be able to analyse and find out how these compounds act, so that one can simplify matters and should be able to show results on a mass scale and,  thereby, saving time and energy.

What, has been discovered is, probably, the tip of the iceberg. Specialists, of all hues, must get involved in this endeavour. With this in view, arrangements must be made. Ultimately, every field of medicine will definitely benefit. A scientifically planned attempt is likely to succeed. Whoever is at the helm of affairs must be fully cognizant of this fact. There is so much yet to be learnt. We hardly know anything about this subject, other than that the condition is responding to this medication and showing progress towards normalcy. Only time can give us the real answer. Till such time, one must patiently continue therapy, while watching and recording evey noticeable change. One more problem has come up. Three have attained menarche. How long they should continue treatment is not known. [After attainment of menarche, one can stop treatment, if pregnancy takes place – the uterine tissues have undergone a metamorphosis and unlikely to revert to its former state. Or else, one should continue treatment for three years by which time, hopefully, the change would have got stabilised. (In India, stabilisation of individual menstrual cycle is established in 3 years unlike in the West, where it takes 6 – 7 years.)]

A Simple Solution for overcoming a birth defect of the generative tract

1.     A medical option is now available, for correcting birth defects of the generative tract.

2.     A doctor trained in Indian native medicine and modern medicine has found a new remedy for these defects.

3.     The option uses 11 compounds which are given in 8 phases after preliminary confirmatory tests.

4.     Serial monthly scans done reveal the progress, made.

5.     Out of 17 cases, having no cavity within uterine nodule, all have developed cavity.

6.     In one case, there was absence of upper vagina, though she had a smaller than normal uterus and in her, complete cavitation of vagina took place connecting it to the uterine cavity and this was confirmed by MRI.

7.      In all cases, there was development of vagina.

8.     Three of these cases have had periods.

9.     Five of them have got married and are awaiting pregnancy. Two more are in the negotiation stage.

10.  No system of medicine has recorded, any option, for developing cavity in rudimentary uterus till date.

11.  Once cavity is created, hormonal medicines may be given.

12. This medical option needs to be highlighted, as this is a welcome step, (giant leap) towards bringing this group of sufferers, back into the mainstream of life.

NB : The Tambaram Branch of Indian Medical Association has highlighted this medical option in its website – www.imatambaram.com.

A Medical Innovation in an era of Innovations

Ayurveda, ‘The Science of Life’, has a divine origin. Over the ages, Sages have divined the medicinal properties of herbs and matter and have postulated compounds, with formularies that have stood the test of time, for various ailments of mankind. Now, in this era of Innovations, a ‘Regime’ of ayurvedic compounds, has been found, which has demonstrated clinical effects, which are not mentioned, in the known actions or uses, of these medical compounds. So, one has to conclude, that this is a ‘divine’ dispensation to alleviate the suffering of those individuals, in whom during development, nature has gone awry. This regime’s notable aspect is that there have been neither deteriorations nor maintenance of status quo, during therapy. In other words, all have shown improvement, albeit at different rates, depending on their fitness and individual physical constitution.

There has been no report in the annals of medical history, wherein, cavitation has taken place in uterus/uterine nodule. This regime has shown not only development of cavity within uterus/uterine nodule but also, formation of cavity in a case of agenesis of upper vagina, from below, upwards. Moreover, lining shedding (menstruation), in women with primary amenorrhoea of anatomic origin, has also taken place.. Hence, this is indeed a pioneering achievement, which needs further scientific evaluation.

One has to approach, in two ways, the solution of this problem. One must continue clinical therapy with the medical compounds used in this regime and simultaneously analyse the ingredients of these formularies. Now, one must stress on the special feature of ayurvedic medicine. There are many compounds in Ayurveda with the same name but with diffeent formularies. Hence, one must make certain, to use only compounds with formularies, mentioned in the regime. In the regime, mention is made of the name of the compound, the chapter and book in which the formulary is given, so that, analysis of results will be reliable. The methodology has to be strictly adhered to, during therapy. This will increase our overall results and spread faith in the regime.

Analyses of compounds, on the other hand, is a long drawn out process, needing tenacity and luck. The phase of the regime, when cavity was noted, would naturally be the first step (since cavity creation is the crux of the innovation). The compounds of this phase have to be studied in detail.

Correction of Mullerian Dysgenesis studied under the following outcomes.

A.     Deterioration.                            Nil.

B.     No  Change.                                 Nil.

C.     Gowth – 1 D.                               Progressive.

D.    Growth – 2 D.                              Ditto.

E.     Growth – 3 D.                              Ditto.

F.     Cavity (alone).                            3 cases.

G.     Cavity & Lining.                          All cases.

H.    Menarche.                                     3 cases.

I.       Pregnancy                                     Nil.

Next, Phase-wise response must be studied. It is given below:

Phase – 1      2  cases.

                2      2  cases. 

                3      4  cases. 

                4      1  case.

                5      1  case.

                6      Nil.

                7      2  cases.

                8      5  cases.

N.B.: The cavity formation is spread over many phases and denotes that the constitution of the individual does play a part. (In ayurveda, constitution or prakrithi, is an important factor in therapy).

Phases and Durations. (of Regime).

(1) 4 months.

(2) 4 months.

(3) 8 months.

(4) 3 months.

(5) 3 months.

(6) 6 months.

(7) 6 months.

(8) 6 months.

NB: All cases have responded. [If any case had not responded at all, the case would have been reviewed and re-assessed and appropriate compounds (as per constitution) given].

At this juncture, one would like to remind the reader that there is a pre-ordained method of development of organs in nature and this ensures that when a stimulus is given, to resume growth, the pattern followed, would be that, of the ordained one. (This point would be substantiated, when review lap is performed, after correction is achieved). In other words, fusion of bilateral nodules or of nodules seen during the first lap would take place on correction. It stands to reason, that this fusion would be by migration of nodules along the mullerian tract to form a single uterus. (In one case, fusion of nodules – one middle and bilateral nodules fused to form a uterus with cavity and lining).

When one phase is over, the next phase medicines given, for duration, dependent on the phase.  When a scan showed increase in any dimension by 0.5 centimeters or more, it is regarded as progress (indicative of suitability of constitution, to the compounds) and the next phase of the regime brought forward (to enhance the changes).

A CLINICAL BREAKTHROUGH

Science is not static and medical science, all the more so and this can be realised by the number of breakthroughs, which have taken place in recent years in the field of clinical medicine. But, not all breakthroughs are accorded recognition straightaway. In this case, the subject matter pertains to a delicate phase of a female’s life, which is usually treated in a secretive way. The non-attainment of menarche (first menstrual flow) is one such, since it has a great bearing on the individual’s life. When it is due to lack of a womb (by birth), it becomes all the more poignant, because there is no ready remedy for it. The defect comes to light, many years after birth (at the time of puberty), or, rarely due to a chance scan revealing the defect. Enquiries made, reveal the fact, that nothing much can be done in such cases. In other words, birth defects cannot be cured but must be endured.

A doctor, qualified in both Allopathy and Ayurveda and who is registered in, both Medical Council of India (MCI) and Central Board of Indigenous Medicine (CBIM), has, by the use of 11 ayurvedic compounds given in 8 phases, created history, by developing cavity and lining within uterine nodule (making it a uterus), as well as created cavity, in upper vagina, which was not present at birth, thus completing its growth and function. This is the crux of the problem, for, now, the individual has entered the pre-menarcheal phase, becomes eligible for hormonal therapy, may spontaneously shed the lining or on initiation of hormonal therapy (neuroendocrine status), thus attaining puberty and womanhood. Now, the last sentence of the previous paragraph needs to be revised.

After obtaining a Patent from the Government of India, he started ‘correction of mullerian dysgenesis’ at A.G.Chromepet Public Health & Maternity Centre at Radha Nagar, Chromepet, Chennai. 600044. (Ph. 044 – 22655503). During correction, clinical examination, laparoscopy, USG Scans, hormonal and other general investigations were done and documented (hard copies are available for easy verification), before administration of medicines. Allopathy has no medical treatment for this condition. The findings were recorded in the computer with the cavity and endometrial thickness in red, to highlight the feat. All the above changes have been documented by USG Scans and in turn MRI to confirm continuity of cavitation between uterus and vagina. The status of the individual has now undergone a radical change and she can hope (earlier, there was no hope) to rejoin the mainstream of normal women in due course.

The results have been staggering, to say the least; for out of 19 cases, one dropped out and in 17 there were development of cavity and lining in the uterine nodule and, in the remaining lone case, where there was agenesis of upper vagina, there has been cavitation of vagina and the same has been confirmed by MRI. The Tambaram branch of the Indian Medical Association has highlighted it, in their website: www.imatambaram.com