Aetiology of Mullerian Dysgenesis – A Theory

The measurements, given by the sonologist, in every case of correction of mullerian dysgenesis (during the monthly scannings over the last 5 years), were graphically recorded. It showed, in all cases, a rise and fall, in every measurement, during correction. A sample graph is given below.

The graph shows the final measurement (be it length, breadth or thickness),in comparison with the starting point, an appreciable improvement, thereby proving that the medicines given, have been beneficial to the patient, as the size of the nodules have grown. This change, by itself, is welcome, since till date, there has been no record of growth of uterine nodule. But, surprisingly, on further scrutiny, we find, that the increase, is neither uniform nor does it show a plateau formation (which is commonly seen), in between spells of growth. In other words, it is not a ladder like growth with occasional landings. On the contrary, it shows regression at many points, occasionally marked. This is surprising and needs a scientific explanation.

Analysis :

Starting Point.

The size of the nodule at the commencement of correction is crucial for the study. The nodule, at that moment, could have been

(1) growing spontaneously,

(2) regressing, or

(3) reached the end point of spontaneous progress  or regression (quiescent or standstill stage), -all of which are possible.

In nature, spontaneous evolution is seen; but then, it offers no explanation for the changes mentioned above (the regression). Similarly, if we consider point (3), having reached the end point, it is unlikely to have any impact on growth, as seen (moreover, having reached the nadir, unlikely to manifest again). So, the only conclusion, that we can make, is, that it was in a regressing phase and hence, retained its regressive element or factor at the commencement of correction and showed it during correction.

Regression Factor.

In nature, we do have a regression factor. In developmental defects of the mullerian tract, the combined incidence of mullerian agenesis, mullerian dysgenesis and regression after eugenesis is given as < 1 %. Regression after eugenesis produces various categories depending on when the regression factor commences to act. So, there is a factor, it has not been isolated or identified, till date. It can continue to act, after birth also. Nature reveals anomalies -  (both fusion & non-fusion defects), segmental loss in the mullerian tract, presence of irregular segments, functional regression (only about 20 % of female babies show withdrawal bleeding), few cases of secondary amenorrhoea with no obvious infection, premature menopause and menopause and finally, atrophy after menopause. Presence of regression factor is evident from the mensurational regression seen, at times, only in one dimension (unexplainable), during the serial scans. 

Growth of Uterine Nodule.

Irrespective of the stage of the starting point, there has been growth of nodule. Normally, in nature, genetic drive is presumed to be the factor for spontaneous evolution on specific lines. Hence, one possibility is that the genetic drive, which has been lying dormant all these years, has been stimulated, by the medicines, resulting in the growth of the nodules.

The Effect of Corrective Medicine.

Dr. Sreevalsan’s Regime has resulted in growth of uterine nodule, in all aspects – size, shape, position (movement towards the midline and anteversion), and development of cavity and lining and finally, response to ovarian hormones (menarche). It, probably, has no action on regression factor, as regression is still seen and it, may be safely presumed, that, it is only, stimulating the genetic drive.

           The Interplay.

During correction, the interplay between genetic stimulation and regressive factor and their relative stengths (at any given moment) could be the deciding factor behind the manifestation seen in the graphs. This is the only explanation that fits the case under discussion. It may be a presumption, but, is definitely, a viable theory. Only time and further study, will prove its true nature.

THERE IS NO GREATER SIGN OF IGNORANCE THAN BELIEVING THAT THE INEXPLICABLE IS IMPOSSIBLE. “   S.BILLARD.